nūhou

Hydroxypropyl beta-cyclodextrin, i ʻike ʻia ʻo (2-hydroxypropyl) -β-cyclodextrin, he ʻātoma hydrogen i loko o nā pūʻulu 2-, 3-, a me 6-hydroxyl o nā koena glucose i loko o ka β-cyclodextrin (β-CD) i pani ʻia e ka hydroxypropyl i hydroxypropoxy.ʻAʻole wale ʻo HP-β-CD ka hopena enveloppe maikaʻi loa ma nā pūhui he nui e like me β-CD, akā loaʻa pū kekahi i nā pono o ka solubility wai kiʻekiʻe a me ka hoʻomaikaʻi ʻana i ka helu hoʻokuʻu a me ka bioavailability o nā lāʻau encapsulated in vivo.Eia kekahi, ʻo HP-β-CD kahi mea hoʻohana lāʻau lapaʻau me ka ʻikepili palekana nui loa i hōʻiliʻili ʻia a ʻaʻohe hopena ʻino.Hiki ke hoʻohana ʻia ʻo HP-β-CD ma ke ʻano he pale pale a me ka stabilizer.

ʻO ka hydroxypropyl beta-cyclodextrin he keʻokeʻo a keʻokeʻo amorphous a i ʻole ka pauka crystalline;ʻAʻala ʻole, ʻono iki;ʻO ka hoʻokomo ʻana i ka wai ikaika.Hiki ke hoʻoheheʻe ʻia kēia huahana i ka wai, hiki ke hoʻoheheʻe ʻia i ka methanol, ethanol, aneane hiki ʻole ke hoʻoheheʻe ʻia i ka acetone, trichloromethane.

Ka hikiwawe ohydroxypropyl -B-cyclodextrini loko o ka wai ua maikai loa, a me ka degere pani o 4 a ma luna hiki ke miscible me ka wai ma kekahi huina, a hiki no hoi ke hoʻoheheʻe 'ia i loko o 50% ethanol a me ka methanol.Loaʻa iā ia kahi hygroscopicity pili.Akā ʻoi aku ka haʻahaʻa o ka hana ʻili a me ka hemolytic.ʻAʻohe ona huhū i ka ʻiʻo a he mea hoʻonui hoʻoheheʻe maikaʻi a me nā mea hoʻohui lāʻau no ka injection.

He aha ka Hydroxypropyl beta-cyclodextrin i hoʻohana ai?

Ma ke kahua o ka meaʻai a me nā mea ʻala

Hiki i ka Hydroxypropyl beta-cyclodextrin ke hoʻomaikaʻi i ke kūpaʻa a me ka hana lōʻihi o nā molekele meaʻai, uhi a hoʻoponopono i ka ʻala maikaʻi ʻole a me ka ʻono o nā molekole meaʻai meaʻai, a hoʻomaikaʻi i ke kaʻina hana a me ka maikaʻi o ka huahana.

I nā mea hoʻonaninani

Hiki ke hoʻohana ʻia nā mea maka o nā mea hoʻonaninani e like me nā stabilizers, emulsifiers, deodorizers, etc., hiki ke hōʻemi i ka hoʻoulu ʻana o nā molekala organik i nā mea hoʻonaninani ma ka ʻili a me nā ʻiʻo mucous membrane, hoʻonui i ka paʻa o nā mea hana, a pale i ka volatilization a me ka oxidation o nā meaʻai. .Loaʻa iā ia kahi hygroscopicity pili.

Ma ke kahua lapaʻau

Hydroxypropyl beta-cyclodextrinhiki ke hoʻomaikaʻi i ka wai hoʻoheheʻe o nā lāʻau lapaʻau ʻole, hoʻonui i ka paʻa o ka lāʻau, hoʻomaikaʻi i ka bioavailability lāʻau, hoʻonui i ka pono o ka hoʻomākaukau ʻana i ka lāʻau lapaʻau a hōʻemi paha i ke ʻano, hoʻoponopono a kāohi i ka wikiwiki o ka hoʻokuʻu ʻana o nā lāʻau lapaʻau, a hoʻemi i ka lāʻau ʻawaʻawa.Hiki ke hoʻohana ʻia e like me ka lawe ʻana i nā lāʻau lapaʻau waha, injections, mucosal drug delivery system (me ka nasal mucosa, rectum, cornea, etc.), transdermal absorption drug delivery system, lipophilic targeted drugs, a hiki ke hoʻohana ʻia ma ke ʻano he pale protein a mea hoʻopaʻa.