Hydroxypropyl beta-cyclodextrin, i ʻike ʻia ʻo (2-hydroxypropyl) -β-cyclodextrin, he ʻātoma hydrogen i loko o nā pūʻulu 2-, 3-, a me 6-hydroxyl o nā koena glucose i loko o ka β-cyclodextrin (β-CD) i pani ʻia e ka hydroxypropyl i hydroxypropoxy. ʻAʻole wale ʻo HP-β-CD ka hopena enveloppe maikaʻi loa ma nā pūhui he nui e like me β-CD, akā loaʻa pū kekahi i nā pono o ka solubility wai kiʻekiʻe a me ka hoʻomaikaʻi ʻana i ka helu hoʻokuʻu a me ka bioavailability o nā lāʻau encapsulated in vivo. Eia kekahi, ʻo HP-β-CD kahi mea hoʻohana lāʻau lapaʻau me ka ʻikepili palekana nui loa i hōʻiliʻili ʻia a ʻaʻohe hopena ʻino. Hiki ke hoʻohana ʻia ʻo HP-β-CD ma ke ʻano he pale pale a me ka stabilizer.
ʻO ka hydroxypropyl beta-cyclodextrin he keʻokeʻo a keʻokeʻo amorphous a i ʻole ka pauka crystalline; ʻAʻala ʻole, ʻono iki; ʻO ka hoʻokomo ʻana i ka wai ikaika. Hiki ke hoʻoheheʻe ʻia kēia huahana i ka wai, hiki ke hoʻoheheʻe ʻia i ka methanol, ethanol, aneane hiki ʻole ke hoʻoheheʻe ʻia i ka acetone, trichloromethane.
Ka hikiwawe ohydroxypropyl -B-cyclodextrini loko o ka wai mea maikai loa, a me ka degere pani o 4 a ma luna hiki ke miscible me ka wai i kekahi like, a hiki no hoi ke hoʻoheheʻe 'ia i loko o 50% ethanol a me ka methanol. Loaʻa iā ia kahi hygroscopicity pili. Akā ʻoi aku ka haʻahaʻa o ka hana ʻili a me ka hemolytic. ʻAʻohe ona huhū i ka ʻiʻo a he mea hoʻonui hoʻoheheʻe maikaʻi a me nā mea hoʻohui lāʻau no ka injection.
He aha ka Hydroxypropyl beta-cyclodextrin i hoʻohana ai?
Ma ke kahua o ka meaʻai a me nā mea ʻala
Hiki i ka Hydroxypropyl beta-cyclodextrin ke hoʻomaikaʻi i ke kūpaʻa a me ka hana lōʻihi o nā molekele meaʻai, uhi a hoʻoponopono i ka ʻala maikaʻi ʻole a me ka ʻono o nā molekole meaʻai meaʻai, a hoʻomaikaʻi i ke kaʻina hana a me ka maikaʻi o ka huahana.
I nā mea hoʻonaninani
Hiki ke hoʻohana ʻia nā mea waiwai o nā mea hoʻonaninani e like me nā stabilizers, emulsifiers, deodorizers, etc., hiki ke hōʻemi i ka hoʻoulu ʻana o nā molekala organik i nā mea hoʻonaninani i ka ʻili a me nā ʻiʻo mucous membrane, hoʻonui i ka paʻa o nā mea hana, a pale i ka volatilization a me ka oxidation o nā meaʻai. . Loaʻa iā ia kahi hygroscopicity pili.
Ma ke kahua lapaʻau
Hydroxypropyl beta-cyclodextrinhiki ke hoʻomaikaʻi i ka wai hoʻoheheʻe o nā lāʻau lapaʻau ʻole, hoʻonui i ka paʻa o ka lāʻau, hoʻomaikaʻi i ka bioavailability lāʻau, hoʻonui i ka pono o ka hoʻomākaukau ʻana i ka lāʻau lapaʻau a hōʻemi paha i ke ʻano, hoʻoponopono a kāohi i ka wikiwiki o ka hoʻokuʻu ʻana o nā lāʻau lapaʻau, a hoʻemi i ka lāʻau ʻawaʻawa. Hiki ke hoʻohana ʻia e like me ka lawe ʻana i nā lāʻau lapaʻau waha, injections, mucosal drug delivery system (me ka nasal mucosa, rectum, cornea, etc.), transdermal absorption drug delivery system, lipophilic targeted drugs, a hiki ke hoʻohana ʻia ma ke ʻano he pale protein a mea hoʻopaʻa.
Ka manawa hoʻouna: Oct-20-2023