nūhou

ʻO ka hydroxypropyl beta-cyclodextrin, i ʻike ʻia hoʻi ʻo (2-hydroxypropyl) -β-cyclodextrin, he ʻātoma hydrogen i loko o nā hui 2-, 3-, a me 6-hydroxyl o nā koena glucose i loko o β-cyclodextrin (β-CD) i pani ʻia e ka hydroxypropyl i hydroxypropoxy. ʻAʻole wale ka hopena envelope maikaʻi loa o HP-β-CD ma nā hui he nui e like me β-CD, akā loaʻa pū kekahi nā pono o ka solubility wai kiʻekiʻe a me ka hoʻomaikaʻi ʻana i ka helu hoʻokuʻu a me ka bioavailability o nā lāʻau i hoʻopaʻa ʻia i loko o vivo. Eia kekahi, ʻo HP-β-CD kahi mea hoʻohui lāʻau me ka ʻikepili palekana ākea loa i hōʻiliʻili ʻia a ʻaʻohe hopena ʻino. Hiki ke hoʻohana ʻia ʻo HP-β-CD ma ke ʻano he mea pale protein a me ka mea hoʻopaʻa.

He keʻokeʻo a keʻokeʻo paha ka pauka amorphous a crystalline paha ka Hydroxypropyl beta-cyclodextrin; ʻAʻohe ʻala, ʻono iki; Hoʻoulu wai ikaika. He maʻalahi ka hoʻoheheʻe ʻana i kēia huahana i ka wai, hiki ke hoʻoheheʻe ʻia i ka methanol, ethanol, aneane hiki ʻole ke hoʻoheheʻe ʻia i ka acetone, trichloromethane.

ʻO ka hiki ke hoʻoheheʻe ʻia ohydroxypropyl-B-cyclodextrini loko o ka wai he maikaʻi loa ia, a hiki ke hui pū ʻia ke kekelē pani o 4 a ʻoi aku me ka wai ma kekahi ʻano, a hiki ke hoʻoheheʻe ʻia i loko o 50% ethanol a me methanol. Loaʻa iā ia kekahi hygroscopicity pili. Akā, haʻahaʻa ka hana o ka ʻili pili a me ka hana hemolytic. ʻAʻohe ona huhū i nā ʻiʻo a he mea hoʻonui solvent kūpono a me ka excipient lāʻau lapaʻau no ka injection.

He aha ka mea e hoʻohana ʻia ai ka Hydroxypropyl beta-cyclodextrin?

Ma ke kahua o ka meaʻai a me nā mea ʻala

Hiki i ka Hydroxypropyl beta-cyclodextrin ke hoʻomaikaʻi i ke kūpaʻa a me ka hana lōʻihi o nā molekala meaʻai, uhi a hoʻoponopono paha i ka ʻala maikaʻi ʻole a me ka ʻono o nā molekala meaʻai meaʻai, a hoʻomaikaʻi i ke kaʻina hana a me ka maikaʻi o ka huahana.

I nā mea hoʻonani

Hiki ke hoʻohana ʻia nā mea maka o nā mea hoʻonani e like me nā mea hoʻopaʻa, nā emulsifier, nā deodorizer, a me nā mea ʻē aʻe, hiki ke hōʻemi i ka hoʻoulu ʻana o nā molekala organik i nā mea hoʻonani ma ka ʻili a me nā ʻiʻo membrane mucous, hoʻonui i ke kūpaʻa o nā mea hana, a pale i ka volatilization a me ka oxidation o nā meaʻai. Loaʻa iā ia kahi hygroscopicity pili.

Ma ke kahua o ka lāʻau lapaʻau

ʻO ka hydroxypropyl beta-cyclodextrinhiki ke hoʻomaikaʻi i ka solubility wai o nā lāʻau lapaʻau insoluble, hoʻonui i ke kūpaʻa o ka lāʻau, hoʻomaikaʻi i ka bioavailability o ka lāʻau, hoʻonui i ka pono o nā hoʻomākaukau lāʻau a hoʻemi paha i ka dosage, hoʻoponopono a kāohi paha i ka wikiwiki o ka hoʻokuʻu ʻana o nā lāʻau, a hoʻemi i ka ʻawahia o ka lāʻau. Hiki ke hoʻohana ʻia ma ke ʻano he mea lawe o nā lāʻau waha, nā injections, nā ʻōnaehana lawe lāʻau mucosal (me ka mucosa nasal, rectum, cornea, etc.), nā ʻōnaehana lawe lāʻau transdermal absorption, nā lāʻau lapaʻau i kuhikuhi ʻia i ka lipophilic, a hiki ke hoʻohana ʻia ma ke ʻano he mea pale protein a me ka mea hoʻopaʻa.