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Hiki paha iā ʻoe ke ʻike liʻiliʻi e pili ana i ka waikawa kojic, akā he ʻohana ʻē aʻe ko ka kojic acid, e like me kojic dipalmitate. ʻO Kojic acid dipalmitate ka mea kaulana loa kojic acid whitening agent ma ka mākeke i kēia manawa. Ma mua o ka ʻike ʻana i ka kojic acid dipalmitate, e aʻo mua kākou e pili ana i ka mea i loaʻa mua - "kojic acid".
Kojic Acidhana ʻia e ka fermentation a me ka hoʻomaʻemaʻe ʻana i ka glucose a i ʻole sucrose ma lalo o ka hana a kojise. ʻO kāna hana keʻokeʻo ke kāohi i ka hana o tyrosinase, ke kāohi i ka hana o ka N-hydroxyindole acid (DHICA) oxidase, a pale i ka polymerization o dihydroxyindole (DHI). He mea keokeo kakaikahi hiki ke pale i na enzymes i ka manawa like.

Akā ʻo kojic acid ka māmā, ka wela a me ka metala ion instability, a ʻaʻole maʻalahi ke komo ʻia e ka ʻili, no laila ua komo mai nā derivatives kojic acid. Ua hoʻomohala ka poʻe noiʻi i nā ʻano kojic acid derivatives e hoʻomaikaʻi i ka hana o kojic acid. Kojic acid derivatives 'a'ole wale ka like whitening mechanical me kojic acid, akā, 'oi aku ka maika'i o ka hana ma mua o kojic acid.
Ma hope o ka esterification me ka kojic acid, hiki ke hana ʻia ka monoester o kojic acid, a hiki ke hana ʻia ka diester. I kēia manawa, ʻo ka kojic acid whitening agent kaulana loa ma ka mākeke ʻo kojic acid dipalmitate (KAD), ʻo ia ka derivative diesterified o kojic acid. Hōʻike ka noiʻi e piʻi nui ana ka hopena keʻokeʻo o KAD i hui pū ʻia me nā derivatives glucosamine.

ʻO ka maikaʻi o ka mālama ʻili o kojic dipalmitate
1) Whitening: ʻOi aku ka maikaʻi o Kojic acid dipalmitate ma mua o ka kojic acid i ke kāohi ʻana i ka hana o tyrosinase i loko o ka ʻili, no laila ke kāohi nei i ka hoʻokumu ʻana o ka melanin, kahi hopena maikaʻi i ka ʻili keʻokeʻo a me ka sunscreen.
2) Ka wehe ʻana i ka freckle: Hiki i ka Kojic acid dipalmitate ke hoʻomaikaʻi i ka ʻili o ka ʻili, a hiki ke hakakā me nā kiko makahiki, nā kiko kiko, nā freckles a me ka pigmentation maʻamau.

ʻO ke alakaʻi hoʻohuihui hoʻonaninani Dipalmitate
Kojic acid dipalmitatepaʻakikī e hoʻohui i ke kumu a maʻalahi ke hana i ka ua aniani. I mea e hoʻoponopono ai i kēia pilikia, pono e hoʻohui i ka isopropyl palmitate a i ʻole isopropyl myristate i ka ʻaila ʻaila i loaʻa ka kojic dipalmitate, e hoʻomehana i ka ʻaila ʻaila i 80 ℃, e paʻa no 5 mau minuke a hiki i ka pau ʻana o kojic dipalmitate, a laila hoʻohui i ka ʻaila ʻaila i ka. ka wai, a emulsify no kahi o 10 mau minuke. ʻO ka maʻamau, ʻo ka pH waiwai o ka huahana hopena i loaʻa ma kahi o 5.0-8.0.
ʻO ka mea i manaʻo ʻia o kojic dipalmitate i nā mea hoʻonaninani he 1-5%; Hoʻohui i ka 3-5% i nā huahana keʻokeʻo.