Metronidazole CAS 443-48-1
He pauka keʻokeʻo a melemele iki paha ka Metronidazole a he pauka crystalline paha; He ʻala iki, me ka ʻono ʻawaʻawa a paʻakai iki. Hoʻoheheʻe iki ʻia i loko o ka ethanol, hoʻoheheʻe iki ʻia i loko o ka wai a i ʻole chloroform, a hoʻoheheʻe iki ʻia i loko o ka ether. He hui heterocyclic i loaʻa ka nitrogen me ka alkalinity a me ka solubility wai haʻahaʻa. Wahi a ke kumumanaʻo prodrug, hana ʻia ka metronidazole i potassium phosphate ester, kahi e hoʻonui ai i kona solubility wai a hiki ke hoʻohana ʻia ma ke ʻano he hopena injection.
| Mea | Nā kikoʻī |
| Kikowaena paila | 301.12°C (manaʻo kikoʻī) |
| Ka nui o ka paʻa | 1.3994 (kuhikuhi maʻamau) |
| Kiko heheʻe | 159-161 °C (mālamalama ʻia) |
| pKa | pKa 2.62(H2O,t =25±0.2, |
| Nā kūlana mālama | 2-8°C |
He hopena antibacterial ikaika ko Metronidazole ma ka hapa nui o nā bacteria anaerobic a hoʻohana ʻia e mālama i ka amoebiasis, trichomoniasis, a me nā maʻi bacteria anaerobic. Hoʻohana ʻia nō hoʻi e mālama i ka trichomoniasis vaginal a ua hoʻohana ʻia no ka amoebiasis ʻōpū a me ka extraintestinal mai ka makahiki 1970. He kiʻekiʻe kona pono, haʻahaʻa ka ʻawahia, a hoʻohana nui ʻia. Loaʻa nā hopena mutagenic a me teratogenic ma nā hoʻokolohua holoholona.
Hoʻopili pinepine ʻia i loko o 25kg / pahu, a hiki ke hana ʻia kahi pūʻolo i hoʻopilikino ʻia.
Metronidazole CAS 443-48-1
Metronidazole CAS 443-48-1
